Impact of single dose of diethylcarbamazine and other antifilarial drug combinations on bancroftian filarial infection variables: assessment after 2 years.
Identifieur interne : 007955 ( Main/Exploration ); précédent : 007954; suivant : 007956Impact of single dose of diethylcarbamazine and other antifilarial drug combinations on bancroftian filarial infection variables: assessment after 2 years.
Auteurs : I P Sunish [Inde] ; R. Rajendran ; T R Mani ; A. Munirathinam ; R. Reuben ; A P DashSource :
- Parasitology international [ 1383-5769 ] ; 2006.
Descripteurs français
- KwdFr :
- Albendazole (administration et posologie), Albendazole (usage thérapeutique), Animaux, Association de médicaments, Diéthylcarbamazine (administration et posologie), Diéthylcarbamazine (usage thérapeutique), Femelle, Filaricides (administration et posologie), Filaricides (usage thérapeutique), Filariose lymphatique (traitement médicamenteux), Humains, Inde, Ivermectine (administration et posologie), Ivermectine (usage thérapeutique), Mâle, Population rurale, Wuchereria bancrofti.
- MESH :
- administration et posologie : Albendazole, Diéthylcarbamazine, Filaricides, Ivermectine.
- traitement médicamenteux : Filariose lymphatique.
- usage thérapeutique : Albendazole, Diéthylcarbamazine, Filaricides, Ivermectine.
- Animaux, Association de médicaments, Femelle, Humains, Inde, Mâle, Population rurale, Wuchereria bancrofti.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- Albendazole (administration & dosage), Albendazole (therapeutic use), Animals, Diethylcarbamazine (administration & dosage), Diethylcarbamazine (therapeutic use), Drug Therapy, Combination, Elephantiasis, Filarial (drug therapy), Female, Filaricides (administration & dosage), Filaricides (therapeutic use), Humans, India, Ivermectin (administration & dosage), Ivermectin (therapeutic use), Male, Rural Population, Wuchereria bancrofti.
- MESH :
- chemical , administration & dosage : Albendazole, Diethylcarbamazine, Filaricides, Ivermectin.
- chemical , therapeutic use : Albendazole, Diethylcarbamazine, Filaricides, Ivermectin.
- geographic : India.
- drug therapy : Elephantiasis, Filarial.
- Animals, Drug Therapy, Combination, Female, Humans, Male, Rural Population, Wuchereria bancrofti.
Abstract
The impact of single dose mass drug administration of diethylcarbamazine (DEC), DEC with albendazole (ALB), and ivermectin (IVR) with albendazole, was examined on the human bancroftian filarial infections in village scale trials in south India, from a follow-up study after 2 years. The treatment arms administered with DEC alone and DEC+ALB demonstrated long-term benefits in reducing microfilaraemia significantly (P<0.05), while antigenaemia reduction was negligible. The arm with ALB+IVR did not show such reductions. Among the antigenaemic and microfilaraemic individuals, 87% became amicrofilaraemic in DEC+ALB arm, which were higher than that observed in the other 2 treatment arms. Among amicrofilaraemics (but Ag+), nearly 35% cleared of infection in DEC+ALB, while 26% and 6% in DEC alone and IVR+ALB arms, respectively. The drug combination DEC+ALB was observed to demonstrate a significant impact in reducing filarial infection even after 2 years post treatment.
DOI: 10.1016/j.parint.2006.05.003
PubMed: 16807079
Affiliations:
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The treatment arms administered with DEC alone and DEC+ALB demonstrated long-term benefits in reducing microfilaraemia significantly (P<0.05), while antigenaemia reduction was negligible. The arm with ALB+IVR did not show such reductions. Among the antigenaemic and microfilaraemic individuals, 87% became amicrofilaraemic in DEC+ALB arm, which were higher than that observed in the other 2 treatment arms. Among amicrofilaraemics (but Ag+), nearly 35% cleared of infection in DEC+ALB, while 26% and 6% in DEC alone and IVR+ALB arms, respectively. The drug combination DEC+ALB was observed to demonstrate a significant impact in reducing filarial infection even after 2 years post treatment.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Dash, A P" sort="Dash, A P" uniqKey="Dash A" first="A P" last="Dash">A P Dash</name><name sortKey="Mani, T R" sort="Mani, T R" uniqKey="Mani T" first="T R" last="Mani">T R Mani</name><name sortKey="Munirathinam, A" sort="Munirathinam, A" uniqKey="Munirathinam A" first="A" last="Munirathinam">A. Munirathinam</name><name sortKey="Rajendran, R" sort="Rajendran, R" uniqKey="Rajendran R" first="R" last="Rajendran">R. Rajendran</name><name sortKey="Reuben, R" sort="Reuben, R" uniqKey="Reuben R" first="R" last="Reuben">R. Reuben</name></noCountry><country name="Inde"><noRegion><name sortKey="Sunish, I P" sort="Sunish, I P" uniqKey="Sunish I" first="I P" last="Sunish">I P Sunish</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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